To achieve molecular mapping of memory in health and disease, we use state-of-the-art techniques that allow for high-resolution investigation, precise manipulation of multiplexed gene targets, and monitoring of phenotypic changes ex vivo and in vivo.

Single cell RNA-seq

CRISPR-Cas9 gene regulation

Optogenetics / Chemogenetics

Behavioral testing

Laser Capture Microdissection

Biochemistry

By integrating approaches such as high-throughput sequencing, opto/chemo-genetics, multiplexed CRISPR gene manipulation, and fluorescent imaging; our lab can both observe and perturb genes and circuits in memory engram formation with high specificity.